. Author manuscript; available in PMC: 2018 Oct 18.

Published in final edited form as: Eur J Pharmacol. 2008 Feb 5;584(2-3):213–221. doi: 10.1016/j.ejphar.2008.01.036

Table 2.

Inhibition kinetic parameters for DL-glyceraldehyde reduction activity of C299S mutant AKR1B10 by various inhibitors

Compound	Inhibition constant (μM)				Mode of inhibition
Compound	IC₅₀	K_ii	K_is	Comparison	Mode of inhibition
Zopolrestat	9.0±0.6	11.0±0.5	12.5±0.5	K_ii≠K_is	mNC
Fenofibrate	10.0±0.5	11.5±0.5	16.5±0.6	K_ii≠K_is	mNC
Wy 14,346	350.0±20.0	360.0±20.0	240.0±10.0	K_ii≠K_is	mNC
Fenofibric acid	220.0±15.0	250.0±10.0	240.0±10.0	K_ii≈K_is	pNC
Gemfibrozil	380.0±20.0	415.0±12.0	370.0±30.0	K_ii≠K_is	mNC
Ciprofibrate	ND	815.0±45.0	705.0±60.0	K_ii≠K_is	mNC

mNC — mixed non-competitive; pNC — pure non-competitive; ND — not detectable; EBPC and sorbinil did not show measurable level of inhibiting C299S mutantAKR1B10.