Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2018 Oct 18.

Published in final edited form as: Psychopharmacology (Berl). 2018 Aug 16;235(10):3017–3030. doi: 10.1007/s00213-018-4992-7

Fig. 2 — Volcano plot for ketamine treatment effect relative to placebo in a healthy controls (q-value < 0.05), b in MDD patients (q-value < 0.10), and c in MDD patients relative to healthy controls (q-value < 0.10). A positive value indicates that either (1) metabolite tended to increase more with ketamine than placebo over time, or (2) metabolite tended to decrease less with ketamine than placebo over time. A negative value indicates either that the metabolite tended to (1) increase less with ketamine than placebo over time, or (2) decrease more with ketamine than placebo over time. The specific pattern can be determined by plotting the time course of the metabolite

Fig. 2 — Volcano plot for ketamine treatment effect relative to placebo in a healthy controls (q-value < 0.05), b in MDD patients (q-value < 0.10), and c in MDD patients relative to healthy controls (q-value < 0.10). A positive value indicates that either (1) metabolite tended to increase more with ketamine than placebo over time, or (2) metabolite tended to decrease less with ketamine than placebo over time. A negative value indicates either that the metabolite tended to (1) increase less with ketamine than placebo over time, or (2) decrease more with ketamine than placebo over time. The specific pattern can be determined by plotting the time course of the metabolite