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. 2018 Oct 11;9:471. doi: 10.3389/fpsyt.2018.00471

Figure 1.

Figure 1

CUMS induced depressive-like behaviors, while minocycline treatment reversed the alteration in both adolescent and adult rats. (A) Sucrose preference percentage in the SPT; (B) Number of crossing in the OFT; (C) Number of rearing in the OFT; (D) Number of grooming in the OFT; (E) Open arm entries ratio in the EPM test; Results were expressed as the mean ± SEM (n = 9 or 10 in each group). #, ##, and ### indicate p < 0.05, p < 0.01, and p < 0.001 vs. C group, respectively; *, **, and *** indicate p < 0.05, p < 0.01, and p < 0.001 vs. S group, respectively. AdoC, adolescent control group; AdoS, adolescent CUMS group; AdoS+M, adolescent CUMS and minocycline group; AduC, adult control group; AduS, adult CUMS group; AduS+M, adult CUMS and minocycline group.