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. 2018 Oct 11;9:471. doi: 10.3389/fpsyt.2018.00471

Figure 4.

Figure 4

CUMS induced microglial activation in the prefrontal cortex and hippocampus of both the adolescent and adult rats, while minocycline reduced the alteration. (A) Iba-1/DAPI (red/blue) staining (× 200) in the prefrontal cortex of adolescent rats; (B) Iba-1/DAPI (red/blue) staining (× 200) in the hippocampus of adolescent rats; (C) Iba-1/DAPI (red/blue) staining (× 200) in the prefrontal cortex of adult rats; (D) Iba-1/DAPI (red/blue) staining (× 200) in the hippocampus of adult rats; (E) Iba-1+ cell counts in the prefrontal cortex; (F) Iba-1+ cell counts in the hippocampus. The results are expressed as the mean ± SEM (n = 5 each group). # and ### indicate p < 0.05 and p < 0.001 vs. C group, respectively; ** and *** indicate p < 0.01 and p < 0.001 vs. S group, respectively. AdoC, adolescent control group; AdoS, adolescent CUMS group; AdoS+M, adolescent CUMS and minocycline group; AduC, adult control group; AduS, adult CUMS group; AduS+M, adult CUMS and minocycline group.