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. Author manuscript; available in PMC: 2018 Nov 30.
Published in final edited form as: Nature. 2018 May 30;558(7708):117–121. doi: 10.1038/s41586-018-0170-7

Figure 2. All single mutations switch sign from detrimental to beneficial in different genetic backgrounds.

Figure 2

a, The same mutation can have different fitness consequences depending on the genetic background. b, Significance of beneficial (blue) or detrimental (red) mutation effects in the backgrounds of each species (left) and across all genetic backgrounds (right). FDR = False Discovery Rate, n = 21,450 backgrounds, see Methods). c, Proportion of genetic backgrounds in which each mutation has beneficial (blue) or detrimental (red) effects.