Table 3. Sulfone and sulfonamide analogues.
Entry | R1 | R2 |
PfPKG IC50 (nM) |
HXI EC50 (nM) |
---|---|---|---|---|
16b | - H | 33 | 4570 | |
16c | 9 | 1560 | ||
16d | 17 | NT | ||
16e | 6 | 1330 | ||
23 | 2 | 113 | ||
Entry | R1 | R2 |
PfPKG IC50 (nM) |
HXI EC50 (nM) |
---|---|---|---|---|
16b | - H | 33 | 4570 | |
16c | 9 | 1560 | ||
16d | 17 | NT | ||
16e | 6 | 1330 | ||
23 | 2 | 113 | ||