. Author manuscript; available in PMC: 2019 Oct 15.

Published in final edited form as: Bioorg Med Chem Lett. 2018 Aug 27;28(19):3168–3173. doi: 10.1016/j.bmcl.2018.08.028

Table 4. In vitro ADME data for compounds 9c, 16a and 23.

Entry	MLM^a (% rem)	HLM^a (% rem)	mLogD (@ pH 7.4)	PAMPA (nm/s)	Kinetic Solubility (µM)
9c	97	91	1.8	75	209
16a	89	84	0.3	0	208
23	89	95	1.9	57	190

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