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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Clin Cancer Res. 2018 Jul 6;24(20):4988–4996. doi: 10.1158/1078-0432.CCR-18-0786

Fig. 2.

Fig. 2

Specific tumor uptake of 89Zr-AMG211 in LS174T tumor bearing mice. A) Representative coronal small-animal PET images up to 24 h after injection of 10 µg 89Zr-AMG211 (n = 6) or 89Zr-Mec14 (n = 6). Li = liver; K = kidney; T = tumor. B) Image quantification of LS174T tumors (upper panel) and blood pool (lower panel). Ex vivo C) biodistribution and D) SDS-PAGE autoradiography 89Zr-AMG211 and 89Zr-Mec14 24 hours after injection. + : 89Zr-tracer prior to injection; - : free 89Zr only; tumor: lysates of 3 different LS174T xenografts; plasma: plasma samples from corresponding mice. Data are mean ± SD. * P ≤ 0.05; ** P ≤ 0.01.