Table 2. Effect of diabetes (hazard ratio [HR] with 95% confidence interval [CI]) on incident major osteoporotic fracture (MOF) or incident hip fracture (HF) controlled for fracture probability using unadjusted FRAX (referent) and four adjustments applied to those with diabetes.

	Diabetes, any duration N = 4136	Diabetes <5 years N = 1323	Diabetes 5-10 years N = 922	Diabetes >10 years N = 1891
	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
MOF prediction, controlled for:
FRAX MOF unadjusted (referent)	1.32 (1.19-1.46)	1.08 (0.89-1.31)	1.24 (1.00-1.55)	1.54 (1.34-1.78)
With RA adjustment	1.02 (0.91-1.13)	0.83 (0.69-1.01)	0.96 (0.77-1.20)	1.19 (1.03-1.37)
With TBS adjustment	1.12 (1.01-1.24)	0.92 (0.76-1.11)	1.05 (0.84-1.31)	1.31 (1.13-1.51)
With T-score lowered 0.5 SD	1.08 (0.98-1.21)	0.89 (0.73-1.08)	1.03 (0.82-1.28)	1.26 (1.09-1.46)
With age raised 10 years	1.01 (0.91-1.12)	0.82 (0.68-1.00)	0.95 (0.76-1.18)	1.19 (1.03-1.37)
HF prediction, controlled for:
FRAX HF unadjusted (referent)	1.76 (1.47-2.10)	1.41 (1.01-1.97)	1.53 (1.05-2.25)	2.12 (1.67-2.68)
With RA adjustment	1.30 (1.09-1.55)	1.04 (0.75-1.45)	1.13 (0.77-1.65)	1.57 (1.25-1.99)
With TBS adjustment	1.48 (1.24-1.77)	1.19 (0.85-1.65)	1.29 (0.88-1.90)	1.78 (1.41-2.26)
With T-score lowered 0.5 SD	1.15 (0.96-1.38)	0.92 (0.66-1.28)	1.01 (0.69-1.47)	1.40 (1.11-1.77)
With age raised 10 years	1.12 (0.94-1.34)	0.88 (0.63-1.22)	0.99 (0.67-1.44)	1.37 (1.08-1.73)

Boldface indicates p-value <0.05. RA, rheumatoid arthritis. TBS, trabecular bone score.