. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: J Bone Miner Res. 2018 Jul 16;33(11):1923–1930. doi: 10.1002/jbmr.3538

Table 4. Reclassification and net reclassification improvement (NRI) for incident major osteoporotic fracture (MOF) or incident hip fracture (HF) using four adjustments applied to those with diabetes (referent unadjusted FRAX). Analyses limited to the diabetes subgroup.

	Reclassified %, total (up, down)	NRI %, fracture cases	NRI %, fracture non-cases	NRI %, overall
	MOF 20%
With RA adjustment	7.1 (7.1, 0.0)	12.2^***	-6.5^***	5.6^**
With TBS adjustment	4.1 (3.5, 0.6)	6.5^***	-2.5^***	3.9^**
With T-score lowered 0.5 SD	6.1 (6.1, 0.0)	11.1^***	-5.5^***	5.6^***
With age raised 10 years	6.7 (6.3, 0.4)	9.8^***	-5.4^***	4.4^*

	HF 3%
With RA adjustment	8.4 (8.4, 0.0)	11.5^***	-8.3^***	3.2
With TBS adjustment	5.7 (5.2, 0.4)	7.2^**	-4.7^***	2.5
With T-score lowered 0.5 SD	11.5 (11.5, 0.0)	12.9^***	-11.4^***	1.5
With age raised 10 years	16.5 (16.4, 0.1)	20.9^***	-16.2^***	4.7

* p-value <0.05, ** p-value <0.01, *** p-value <0.001. Boldface indicates p-value <0.05. RA, rheumatoid arthritis. TBS, trabecular bone score.