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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2018 Apr 25;1870(1):88–95. doi: 10.1016/j.bbcan.2018.04.010

Figure 1. p62 in the tumor epithelia.

Figure 1

p62 is transcriptionally regulated by inflammation and stress acting via upstream activators (eg, AP1, NFκB and NRF2) that are repressed under homeostatic conditions. Autophagy impairment promotes p62 accumulation and de-repression of the p62 activators, leading to further p62 expression. p62 is also frequently found amplified within the 5q amplicon in ccCRC. p62 downstream functions include activation of NFκB to activate pro-survival pathways, mTORC1 to activate cell growth and proliferation and NRF2 to drive genes of redox detoxification and metabolic pathways.