FIG 1.
Effect of oral administration of P. gingivalis on gut microbiota composition. Male C57BL/6 mice (7/group) were orally administered with either 109 CFU of live P. gingivalis or vehicle twice a week for 5 weeks. Fecal samples were subjected to 16S rRNA sequencing. (A) Relative abundances of bacterial groups at the genus level in the P. gingivalis- and sham-administered groups. (B) Bar plots for genera that exhibited significant differences in relative abundances between the groups. *, P < 0.05; **, P < 0.01, Mann-Whitney U test. (C) Linear discriminant analysis (LDA) scores derived from the LEfSe analysis. (D) PCoA of fecal microbiota from the two groups of mice using unweighted UniFrac distances (ANOSIM test). (E) PCoA of fecal microbiota from the two groups of mice using Bray-Curtis distances (ANOSIM test). Pg, P. gingivalis-administered mice; Sham, sham-administered mice; Unc., unclassified.