Fig 7.

A proposed model of FANCD2 and FANCI recruitment and activation at ICLs via UHRF1 and UHRF2. UHRF1 and UHRF2 are rapidly and independently recruited to the site of the ICL. Recruitment of UHRF1 and UHRF2 facilitate recruitment/retention of the FANCD2/FANCI complex. When FANCD2 and FANCI are bound at the ICL a putative conformational change allows for monoubiquitination by the core complex. The now active FANCD2/FANCI complex activates downstream repair proteins, leading to repair of the ICL.