Table 1. Top 10 enriched biological processes (BP) and enriched KEGG pathways identified by STRING database using the 89 genes shared among the reported results from Cánovas et al. (2014) [13], Hawken et al. (2012) [22] and Nguyen et al. (2017) [20] and mapped in regions with 5 or more categories of QTL.

Top 10 enriched GO (Biological Function)
ID	Description	Bonferroni P-value	Implicated genes
GO:0048513	Organ development	8.67E-05	ABI1, ABL1, ACTB, ACTL6B, ADAMTS18, ATF2, CAPN3, CCDC85C, CHD7, CUX1, DCHS1, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LIN7A, MYC, NTRK1, POU3F1, PPARG, PRKG1, RBM20, RP1, RSPO2, SPINT1, TBL1XR1, TG, ZNF148
GO:0048731	System development	0.0002	ABI1, ACTB, ACTL6B, ADAMTS18, ADCYAP1, ATF2, BARHL2, BMP7, CAPN3, CCDC85C, CHD7, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LGALS3, LIN7A, MYC, OPCML, PDLIM5, PPARG, PRICKLE1, PRKG1, RBM20, RP1, RSPO2, SCG2, SPINT1, TBL1XR1, TG, TRPC7, ZNF148
GO:0007275	Multicellular organismal development	0.0003	ABI1, ACTB, ACTL6B, ADAMTS18, ADCYAP1, ATF2, BARHL2, BMP7, CAPN3, CCDC85C, CHD7, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LGALS3, LIN7A, MYC, OPCML, PDLIM5, PPARG, PRICKLE1, PRKG1, RBM20, RP1, RSPO2, SCG2, SMAD2, SPINT1, TBL1XR1, TG, TLL2, TRPC7, ZNF148
GO:0048856	Anatomical structure development	0.0003	ABI1, ACTB, ACTL6B, ADAMTS18, ADCYAP1, ATF2, BARHL2, BMP7, CAPN3, CASR, CCDC85C, CHD7, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LIN7A, LMOD2, MYC, OPCML, PDLIM5, PPARG, PRICKLE1, PRKG1, RBM20, RP1, RSPO2, SCG2, SMAD2, SPINT1, TBL1XR1, TG, TRPC7, ZNF148
GO:0044707	Single-multicellular organism process	0.0004	ABI1, ACTB, ACTL6B, ADAMTS18, ADCYAP1, ATF2, BARHL2, BMP7, BRPF3, CAPN3, CASR, CCDC85C, CHD7, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LGALS3, LIN7A, LMOD2, MYC, NPAS3, OPCML, PDLIM5, PGAM2, PNKD, PPARG, PRICKLE1, RBM20, RP1, RSPO2, SCG2, SMAD2, SPINT1, SST, TBL1XR1, TG, TLL2, TRPC7, ZNF148
GO:0009888	Tissue development	0.0007	ABI1, ATF2, CHD7, CUX1, DCHS1, FKBP1A, FOLR1, GSK3B, HHEX, IGF1R, LGALS3, MYC, NTRK1, POU3F1, PPARG, PRICKLE1, RP1, RSPO2, SPINT1, TBL1XR1, TDGF1
GO:0032502	Developmental process	0.001	ABI1, ACTB, ACTL6B, ADAMTS18, ADCYAP1, ATF2, BARHL2, BMP7, CASR, CCDC85C, CHD7, EMX2, FKBP1A, FOLR1, FSHR, GSK3B, HHEX, IGF1R, LIN7A, LMOD2, MYC, NPAS3, OPCML, PDLIM5, PPARG, PRICKLE1, PRKG1, RBM20, RP1, RSPO2, SCG2, SMAD2, SPINT1, TBL1XR1, TG, TLL2, TRPC7, ZNF148
GO:0060429	Epithelium development	0.001	ABI1, CHD7, CUX1, DCHS1, FOLR1, HHEX, IGF1R, LGALS3, MYC, NTRK1, POU3F1, PPARG, PRICKLE1, RSPO2, SMAD2, SPINT1
GO:0035239	Tube morphogenesis	0.003	BMP7, CHD7, DCHS1, FOLR1, HHEX, MYC, PRICKLE1, RSPO2, SMAD2, SPINT1
GO:0006468	Receptor activity	0.003	ABI1, ABL1, ATF2, DAPK2, GSK3B, IGF1R, MYC, NTRK1, PRKG1, SCG2, SMAD2, STK32B, STK33, TDGF1
Enriched KEGG Pathways
KEGG: 5202	Transcriptional misregulation in cancer	0.00183	HHEX, IGF1R, MYC, NTRK1, PPARG, SPINT1, SUPT3H
KEGG: 5200	Pathways in cancer	0.00943	ABL1, DAPK2, GSK3B, IGF1R, MYC, NTRK1, PPARG, SMAD2
KEGG: 5216	Thyroid cancer	0.0193	MYC, NTRK1, PPARG
KEGG: 4390	Hippo signaling pathway	0.0286	ACTB, BMP7, GSK3B, MYC, SMAD2