Table 1. Characteristics of the included studies.
| Author | Y of publication | Sample size | Jadad score | Dose and route of octreotide | Definition of the POPF | THE POPF (octreotide vs. control) |
|---|---|---|---|---|---|---|
| Kurumboor et al, | 2015 | 109 | 3 | 100 microgram octreotide SC, 8 h for 5 d | As per ISGPF definition | 33/55 vs. 34/54 ( p = 0.626) |
| Fernández-Cruz et al | 2013 | 62 | 3 | 100 microgram octreotide SC, 8 h for 10 d | As per ISGPF definition | 2/32 vs. 3/30, ( p = 0.769) |
| Kollmar et al | 2008 | 65 | 5 | 100 microgram octreotide SC, 8 h for 7 d | As per ISGPF definition | 9/35 vs. 6/32 ( p = NS) |
| Hesse et al | 2005 | 80 | 3 | 100 microgram octreotide SC, 8 h for 7 d | >100 mL/day of amylase rich fluid (> 5 times upper limit of normal serum amylase after d 3, persisting after d 7 with rising temperature and preseptic condition | 5/41 vs. 3/39 ( p = NS) |
| Suc et al | 2004 | 177 | 4 | 100 microgram octreotide SC, 8 h for 10 d | Amylase rish fluid (> 4 times upper limit of normal serum amylase after d 3 | 18/92 vs. 18/85 ( p = NS) |
| Yeo et al | 2000 | 211 | 5 | 250 microgram octreotide SC, 8 h for 7 d | > 50 mL/day of amylase rich fluid (> 3 times upper limit of normal serum amylase after d 10, or pancreatic anastomotic disruption demonstrated radiologically | 11/104 vs. 10/107 ( p = NS) |
| Lowy et al | 1997 | 110 | 3 | 150 microgram octreotide SC, 8 h for 5 d | Amylase rich fluid (> 2.5 times upper limit of normal serum amylase after d 3 | 16/57 vs. 11/53 ( p = 0.23) |
| Montorsi et al | 1995 | 143 | 4 | 100 microgram octreotide SC, 8 h for 7 d | > 10 mL/day of amylase rich fluid (> 3 times of normal serum amylase after d 3 | 8/76 vs. 10/67 ( p = NS) |
Abbreviations: ISGPF, International Study Group for Pancreatic Fistula; NS, not significant; POPF, postoperative pancreatic fistula; SC, subcutaneously.