Table 1.
Baseline Characteristics of the VITAL CTSC, TBS Sub-cohort adjusted for age, sex/gender, Black race/ethnicity, and BMI
| Variable | Total (%) | TBS mean (95% CI) | P- value |
|---|---|---|---|
| Sex | N=672 | <0.001* | |
| Male | 369 (54.91%) | 1.311 (1.287 – 1.335) | |
| Female | 303 (45.09%) | 1.278 (1.253 – 1.302) | |
| Age | N=672 | 0.004* | |
| 50–54 | 50 (7.44%) | 1.321 (1.291 – 1.351) | |
| 55–59 | 149 (22.17%) | 1.307 (1.283 – 1.330) | |
| 60–64 | 218 (32.44%) | 1.285 (1.261 – 1.308) | |
| 65–69 | 168 (25.00%) | 1.287 (1.262 – 1.311) | |
| 70–74 | 58 (8.63%) | 1.267 (1.236 – 1.299) | |
| 75–79 | 23 (3.42%) | 1.266 (1.227 – 1.305) | |
| 80–84 | 6 (0.89%) | 1.328 (1.257 – 1.400) | |
| Race/Ethnicity | N=661 | 0.16 | |
| Non-Hispanic White | 549 (83.06%) | 1.303 (1.282 – 1.325) | |
| African American/Black | 58 (8.77%) | 1.288 (1.258 – 1.318) | |
| BMI | N=672 | <0.001* | |
| <18.5 | 4 (0.60%) | 1.320 (1.235 – 1.405) | |
| 18.5–24.9 | 187 (27.83%) | 1.355 (1.335 – 1.374) | |
| 25–29.9 | 310 (46.13%) | 1.324 (1.306 – 1.341) | |
| 30–34.9 | 148 (22.02%) | 1.277 (1.257 – 1.297) | |
| 35–37.0 | 23 (3.42%) | 1.197 (1.159 – 1.235) | |
|
History of fragility fracture at baseline |
N=655 | 0.072 | |
| No | 601 (91.76%) | 1.297 (1.273 – 1.320) | |
| Yes | 54 (8.24%) | 1.274 (1.242 – 1.307) | |
| Diabetes | N=664 | 0.008* | |
| No | 602 (90.66%) | 1.296 (1.273 – 1.320) | |
| Yes | 62 (9.34%) | 1.265 (1.235 – 1.295) | |
| Multivitamin use | N=634 | 0.87 | |
| No | 354 (55.84%) | 1.292 (1.267 – 1.316) | |
| Yes | 280 (44.16%) | 1.290 (1.265 – 1.316) | |
| Caffeine use | N=634 | 0.68 | |
| Never | 54 (8.52%) | 1.282 (1.250 – 1.314) | |
| >0- ⩽1 servings/day | 161 (25.39%) | 1.294 (1.269 – 1.320) | |
| >1- ⩽2.5 servings/day | 208 (32.81%) | 1.290 (1.263 – 1.317) | |
| >2.5- ⩽3.5 servings/day | 142 (22.40%) | 1.301 (1.272 – 1.330) | |
| >3.5 servings/day | 69 (10.88%) | 1.290 (1.259 – 1.322) | |
| Smoking status | N=668 | 0.28 | |
| Never | 342 (51.20%) | 1.300 (1.276 – 1.325) | |
| Past | 284 (42.51%) | 1.291 (1.266 – 1.316) | |
| Current | 42 (6.29%) | 1.285 (1.250 – 1.319) | |
| Alcohol use | N=634 | 0.009* | |
| Never / Rarely | 118 (18.61%) | 1.274 (1.247 – 1.301) | |
| 1–3/ month | 43 (6.78%) | 1.297 (1.262 – 1.331) | |
| 1/ week | 77 (12.15%) | 1.294 (1.265 – 1.323) | |
| 2–4/ week | 115 (18.14%) | 1.295 (1.267 – 1.324) | |
| 5–6/ week | 71 (11.20%) | 1.305 (1.274 – 1.336) | |
| Daily | 93 (14.67%) | 1.308 (1.278 – 1.338) | |
| 2–3/ day | 97 (15.30%) | 1.305 (1.275 – 1.335) | |
| 4–5/ day | 14 (2.21%) | 1.268 (1.215 – 1.321) | |
| 6+ /day | 6 (0.95%) | 1.199 (1.127 – 1.271) | |
| Total MET-hrs/week categories | N=669 | 0.19 | |
| 1st tertile (0–13.71) | 223 (33.33%) | 1.288 (1.264 – 1.313) | |
| 2nd tertile (13.72–32.48) | 223 (33.33%) | 1.297 (1.272 – 1.323) | |
| 3rd tertile (≥32.49) | 223 (33.33%) | 1.303 (1.278 – 1.329) | |
| SSRI use | N=662 | 0.044* | |
| No | 609 (91.99%) | 1.295 (1.272 – 1.319) | |
| Yes | 53 (8.01%) | 1.270 (1.236 – 1.304) | |
| Falls in the past year | N=638 | 0.35 | |
| None | 519 (81.35%) | 1.292 (1.267 – 1.316) | |
| One fall | 92 (14.42%) | 1.281 (1.251 – 1.310) | |
| Two falls | 15 (2.35%) | 1.322 (1.273 – 1.372) | |
| Three falls | 12 (1.88%) | 1.285 (1.231 – 1.339) |
*
p < 0.05
p-values for African-American/ Black and Non-Hispanic white are the comparison to all other race/ethnicity groups
Abbr: BMI, body mass index; MET, metabolic equivalent; SSRI, selective serotonin reuptake inhibitor