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. 2018 Oct 6;175(22):4253–4265. doi: 10.1111/bph.14491

Figure 3.

Figure 3

Effects of chronic IFNγ administration on KAT activity. Concentration‐dependent effects of chronic IFNγ administration (for 7 days) on KAT activity index is indicated in (A). KAT activity index was calculated as the ratio of kynurenic acid:kynurenine from results in Study 1. After incubation in culture medium containing 1 μM kynurenine plus IFNγ for 7 days, concentration‐dependent effect of chronic IFNγ administration (for 7 days) on astroglial kynurenic acid release is indicated in (B). Concentration‐dependent effects of chronic IFNγ administration on KAT activity index and astroglial kynurenic acid release were analysed using one‐way ANOVA followed by Tukey's post hoc test. *P < 0.05 versus control (free IFNγ) (N = 12). In this study (Study 2), astrocyte cultures prepared from the same rat were administered different agents.