Figure 5.
Interaction between chronic administration of IFNγ and LEV on astroglial release of kynurenine‐pathway metabolites. After incubation in culture medium containing LEV (10, 30 and 100 μM) with or without 100 U·mL−1 IFNγ for 7 days; concentration‐dependent effects of LEV (0, 10, 30 and 100 μM) on astroglial release of kynurenine and kynurenic acid are indicated in (A) and (B) respectively. Concentration‐dependent effects of LEV on astroglial releases of kynurenine‐pathway metabolites were analysed using two‐way ANOVA followed by Tukey's post hoc test. *P < 0.05 versus control (free LEV), #P < 0.05 versus LEV + IFNγ (n = 12). In this study (Study 4), different agents were administered to astrocyte cultures prepared from the same rat.