Figure 6.
Interaction between chronic administration of IFNγ and LEV on astroglial release of kynurenine‐pathway metabolites under the application of 3OH‐kynurenine. After incubation in culture medium containing 1 μM 3OH‐kynurenine, LEV (10, 30 and 100 μM) with or without 100 U·mL−1 IFNγ for 7 days; concentration‐dependent effects of chronic administration of LEV (10, 30 and 100 μM) on astroglial release of xanthurenic acid, cinnabarinic acid and quinolinic acid are indicated in (A–C) respectively. Concentration‐dependent effects of LEV on astroglial release of kynurenine‐pathway metabolites were analysed using two‐way ANOVA followed by Tukey's post hoc test (n = 12). *P < 0.05 versus control (free LEV) (n = 12). In this study (Study 4), different agents were administered to astrocyte cultures prepared from the same rat.