Figure 7.

Time‐dependent effects of acute LEV administration on AMPA‐ and AdA‐induced astroglial release of kynurenine‐pathway metabolites. Time‐dependent effects of acute 100 μM LEV administration on 100 μM AMPA‐ and 1 μM AdA‐induced astroglial release of kynurenic acid, xanthurenic acid, cinnabarinic acid and quinolinic acid are indicated in (A–D) respectively. AMPA‐ and AdA‐evoked release of kynurenine‐pathway metabolites were calculated by subtraction of basal release from the astroglial release after AMPA‐ and AdA‐evoked stimulation (for 60 min). *P < 0.05 versus control by two‐way ANOVA followed by Tukey's post hoc test (n = 12). In this study (Study 5), different agents were administered to astrocyte cultures prepared from the same rat.