Figure 8.

Interaction between chronic administration of LEV and IFNγ on AMPA‐ and AdA‐induced astroglial release of kynurenine‐pathway metabolites. Interaction between incubation of 100 U·mL⁻¹ IFNγ and 100 μM LEV for 7 days on 100 μM AMPA‐ and 1 μM AdA‐induced astroglial release of kynurenic acid, xanthurenic acid, cinnabarinic acid and quinolinic acid are indicated in (A–D) respectively. AMPA‐ and AdA‐evoked release were calculated by subtraction of basal release (opened columns) from the astroglial release during AMPA‐ and AdA‐evoked stimulation. *P < 0.05 versus control, #P < 0.05 versus IFNγ by two‐way ANOVA followed by Tukey's post hoc test (n = 12). In this study (Study 6), different agents were administered to the astrocyte cultures prepared from the same rat.