Figure 1.
Effects of LPA on the mediator of FID in non‐CAD human adipose arterioles. (A) L‐NAME inhibits peak FID in control vessels, but Peg‐Cat has no effect. (B) In vessels treated with LPA (10 μM, 30 min), Peg‐Cat significantly reduces peak FID. Presence of L‐NAME in LPA‐treated vessels significantly improved FID but only at the 20 cmH2O of pressure gradient. (C) Dilation to ACh is significantly decreased in arterioles treated with LPA in comparison to control arterioles. (D) Dilation to SNP is not different between control and LPA‐treated vessels. *P < 0.05 versus control at specific pressure gradients, # P < 0.05 versus control at 20 cmH2O pressure gradient (L‐NAME curve), P = NS between 1st and 2nd curve at each pressure gradient; n is shown in parentheses.