Table 2.

Diversity statistics across the different domains of the var2csa gene in 1,249 isolates of P. falciparum.

Domain	Length in amino acids in 3D7 reference	Region in alignment	% of InDel positions	Mean length	Standard Deviation (length)	Positions without missing data	Variant Sites	Variant Sites (%)	No. Haplotypes (n = 1,249)	Haplotype Diversity (Hd)	Nucleotide diversity (π)
NTS	50	1–153	3	151.2	1.3	132	48	36	285	0.977	0.105
DBL1X	429	154–1852	36	1300.0	7.8	856	391	46	436	0.986	0.115
ID1	14	1853–1907	98	42.6	3.9	56	1	2	2	0.003	0.003
DBL2X	466	1908–5844	61	1428.4	39.7	657	188	29	437	0.986	0.071
CIDR	255	5845–6670	13	769.0	1.6	636	207	33	436	0.986	0.103
DBL3X	358	6671–8253	30	1102.2	21.6	890	172	19	449	0.986	0.044
DBL4X	372	8254–9568	27	1103.9	14.9	808	121	15	450	0.986	0.032
ID2	40	9569–9691	0	122.0	0	122	25	20	133	0.958	0.045
DBL5X	298	9692–10799	32	885.3	37.6	668	202	30	414	0.986	0.063
ID3	20	10800–10863	13	58.8	3.3	56	32	57	56	0.919	0.193

InDel Insertions and deletions; Bolded is the CSA minal binding-domain.