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. 2018 Oct 18;8:15458. doi: 10.1038/s41598-018-33453-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The AMPK T172 and P70S6K T389 phosphorylation levels after overnight treatment with 0 to 20 μM LSN3213128 in (A) NCI-H460, (C) MDA-MB-231met2, and (E) A9 using RPMI media, i.e. regular folate conditions. The levels of total actin, AMPKα and P70S6K are also shown. The anti-proliferative effect of LSN3213128 with (blue) and without (red) hypoxanthine in tissue culture are shown as measured using Alamar Blue in (B) NCI-H460, (D) MDA-MB-231met2, and (F) A9. Full images and the croppings used in this figure are shown in Supplemental Figures S4–S13.