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. 2018 Oct 18;8:15458. doi: 10.1038/s41598-018-33453-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacodynamic response of ZMP (purple), AICAR (blue), SAICAR (green), dUMP (red), AMP (aqua) & GMP (orange) metabolites in tumors following a single PO dose of LSN3213128 in athymic nude mice. The dose response for the above metabolites following a PO dose of LSN3213128 at 4 hours are shown for (A) NCI-H460 on low folate chow, (C) A9 on standard chow, (E) MDA-MB-231met2 on standard chow. The time course for the above metabolites following a PO dose of LSN3213128 are shown for (B) NCI-H460 at 1 mg/kg on low folate chow, (D) A9 at 30 mg/kg on standard chow, (F) MDA-MB-231met2 at 30 mg/kg on standard chow. A * above the bar indicates a p-value < 0.05 using mean comparisons to vehicle control, Dunnett’s method using JMP 12.1.0.