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. 2018 Oct 18;8:15458. doi: 10.1038/s41598-018-33453-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The anti-tumor effect of LSN3213128 dosed orally in mice are shown using the following models: (A) NCI-H460 at 10 (red), 30 (green) and 60 (blue) mg/kg BIDx13, (C) A9 at 100 (red) mg/kg BIDx12 and (E) MDA-MB-231met2 at 30 (red) and 60 (green) mg/kg BIDx22. Vehicle is in black. A * next to the % T/C indicates a p-value < 0.05 compared to vehicle control. The ZMP (purple), AICAR (blue), SAICAR (green), dUMP (red), ATP (dark green), AMP (aqua), GTP (brown), GMP (orange) & ZTP (plum) metabolite levels following LSN3213128 for the treatment groups above are shown for B) NCI-H460, D) A9 and F) MDA-MB-231met2. A * above the bar indicates a p-value < 0.05 using mean comparisons to vehicle control, Dunnett’s method using JMP 12.1.0.