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. 2018 Oct 18;8:15458. doi: 10.1038/s41598-018-33453-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The AMPK T172 and P70S6K T389 phosphorylation levels after 100 mg/kg BIDx12 PO dose of LSN3213128 are shown for A9 tumors. The levels of total AMPKα and P70S6K are also shown. (B) The AMPK T172 phosphorylation levels after 30 and 60 mg/kg BIDx22 PO dose of LSN3213128 are shown for MDA-MB-231met2 tumors. The levels of total AMPKα are also shown. (C) Plot of ATP/AMP ratio after 30 and 60 mg/kg BIDx22 PO dose of LSN3213128 from MDA-MB-231met2 tumors are shown using mean comparisons to vehicle control, Dunnett’s method using JMP 12.1.0. (D) A plot shows tumor volume for human large cell lung cancer NCI-H460 (blue X), human triple negative breast cancer MDA-MB231met2 (black circles) and murine A9 tumor (red triangle) vs ZMP levels. The black solid line is a fit of the human MDA-MB-231met2 and NCI-H460 data to a three parameter logistic with an IC₅₀ of 108 ± 78 uM, a Max of 1490 ± 120 mm³ and a Min of 125 ± 262 mm³. Full images and the croppings used in this figure are shown in Supplemental Figures S14–S21.