Table 1.
LSN3213128 activity in tissue culture.
| Cell line | ZMP EC50 (nM) Low folate | ZMP EC50 (nM) Regular folate | Alamar Blue GI50 (nM) Low folate | Alamar Blue GI50 (nM) Regular folate |
|---|---|---|---|---|
| HCT 116 (colon) | 2.7 ± 3.3 | 369 ± 44 | 2.2 ± 2.1 | 2811 ± 1220 |
| SW620 (colon) | 4.3 ± 0.9 | 600 | 8.8 ± 1.6 | 3910 ± 3239 |
| SNU-16 (gastric) | 2 | 2500 | 1.2 ± 1.2 | 1590 ± 1273 |
| A549 (lung) | 10 | 3100 | 6 | — |
| NCI-H1155 (lung) | 2.3 | 380 | 4.9 | 729 ± 215 |
| NCI-H1299 | 4.1 | — | 4.8 | 1590 |
| NCI-H1437 (lung) | 4.6 | 620 ± 354 | 0.73 | 1883 ± 894 |
| NCI-H1993 (lung) | 7.1 | — | 3.0 ± 2.7 | 2676 ± 2537 |
| NCI-H460 (lung) | 8 | 428 ± 102 | 16.4 ± 5.1 | 3470 ± 2092 |
| MDA-MB-231 (mammary) | 7.6 | 89 | 0.49 | 85 ± 42 |
| A101D (melenoma) | 2.3 | — | 2.9 | 3290 |
| MIA PaCa-2 (pancreas) | 4.2 | 1700 | 1.6 ± 1.0 | 4870 ± 4200 |