Table 1.
Set (suppl. info) | GO-term | Description | Enrichment |
---|---|---|---|
All GC-genes (3F) | GO:0006139 | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process | 14.21 |
GO:0000279 | M-phase | 5.73 | |
GO:0006302 | Double-strand break repair | 3.04 | |
GO:0006259 | DNA metabolic process | 2.70 | |
GO:0048610 | Reproductive cellular process | 2.50 | |
GO:0007156 | Homophilic cell adhesion | 1.55 | |
25% most widely expressed in cancer (3G) | GO:0044260 | Cellular macromolecule metabolic process | 3.90 |
GO:0022403 | Cell cycle phase | 3.59 | |
GO:0032446 | Protein modification by small protein conjugation | 1.78 | |
GO:0006974 | Response to DNA damage stimulus | 1.51 | |
GO:0007017 | Microtubule-based process | 1.44 | |
GO:0000075 | Cell cycle checkpoint | 1.41 | |
Cluster 1 (3B)a | GO:0007156 | Homophilic cell adhesion | 4.70 |
GO:0006350 | Transcription | 3.97 | |
GO:0016339 | Calcium-dependent cell–cell adhesion | 1.73 | |
GO:0050953 | Sensory perception of light stimulus | 1.62 | |
GO:0001539 | Ciliary or flagellar motility | 1.39 | |
Cluster 2 (3C)a | GO:0006350 | Transcription | 19.47 |
Cluster 3 (3D)a | GO:0000279 | M-phase (mitosis) | 18.63 |
GO:0000279 | M-phase (meiosis) | 16.60 | |
GO:0006259 | DNA metabolic process | 5.41 | |
GO:0010564 | Regulation of cell cycle process | 4.47 | |
GO:0007017 | Microtubule-based process | 4.47 | |
GO:0006310 | DNA recombination | 4.32 | |
GO:0033043 | Regulation of organelle organization | 2.72 | |
GO:0000075 | Cell cycle checkpoint | 2.38 | |
Cluster 4 (3E)a | GO:0051327 | M-phase of meiotic cell cycle | 1.97 |
GO:0019953 | Sexual reproduction | 1.71 | |
GO:0043046 | DNA methylation during gametogenesis | 1.61 | |
GC-genes encoding cell surface proteins (4B) | GO:0051239 | Regulation of multicellular organismal processb | 1.78 |
GO:0051239 | Regulation of multicellular organismal processb | 1.58 | |
GO:0006836 | Neurotransmitter transport | 1.49 | |
GC-genes not detected in whole testis (5B) | GO:0045449 | Regulation of transcription | 8.07 |
GO:0007156 | Homophilic cell adhesion | 3.04 | |
GO:0045494 | Photoreceptor cell maintenance | 1.45 | |
Cancer-specific genes that are not GC-genes (7B) | GO:0006955 | Immune response | 2.24 |
Summary of gene ontology (GO) analysis of GC-genes. Enrichment equals −log10(p), where 1.3 is equivalent to p = 0.05 and p represents the geometric mean of p-values in an annotation cluster. Only a description of the first term of each statistically significant (enrichment > 1.3) annotation cluster is shown. Full results are shown in corresponding supplementary data for each subset (3B–G, 4B, 5B, and 7B)
aAs referred to in Fig. 1
bThese annotation clusters are not exactly the same, but both include the same GO-term, which has the lowest p-value in each cluster