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. 2018 Jun 15;37(42):5694–5700. doi: 10.1038/s41388-018-0357-2

Table 1.

GC-genes represent processes that are likely to contribute to tumor cell survival, proliferation, and metastasis

Set (suppl. info) GO-term Description Enrichment
All GC-genes (3F) GO:0006139 Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process 14.21
GO:0000279 M-phase 5.73
GO:0006302 Double-strand break repair 3.04
GO:0006259 DNA metabolic process 2.70
GO:0048610 Reproductive cellular process 2.50
GO:0007156 Homophilic cell adhesion 1.55
25% most widely expressed in cancer (3G) GO:0044260 Cellular macromolecule metabolic process 3.90
GO:0022403 Cell cycle phase 3.59
GO:0032446 Protein modification by small protein conjugation 1.78
GO:0006974 Response to DNA damage stimulus 1.51
GO:0007017 Microtubule-based process 1.44
GO:0000075 Cell cycle checkpoint 1.41
Cluster 1 (3B)a GO:0007156 Homophilic cell adhesion 4.70
GO:0006350 Transcription 3.97
GO:0016339 Calcium-dependent cell–cell adhesion 1.73
GO:0050953 Sensory perception of light stimulus 1.62
GO:0001539 Ciliary or flagellar motility 1.39
Cluster 2 (3C)a GO:0006350 Transcription 19.47
Cluster 3 (3D)a GO:0000279 M-phase (mitosis) 18.63
GO:0000279 M-phase (meiosis) 16.60
GO:0006259 DNA metabolic process 5.41
GO:0010564 Regulation of cell cycle process 4.47
GO:0007017 Microtubule-based process 4.47
GO:0006310 DNA recombination 4.32
GO:0033043 Regulation of organelle organization 2.72
GO:0000075 Cell cycle checkpoint 2.38
Cluster 4 (3E)a GO:0051327 M-phase of meiotic cell cycle 1.97
GO:0019953 Sexual reproduction 1.71
GO:0043046 DNA methylation during gametogenesis 1.61
GC-genes encoding cell surface proteins (4B) GO:0051239 Regulation of multicellular organismal processb 1.78
GO:0051239 Regulation of multicellular organismal processb 1.58
GO:0006836 Neurotransmitter transport 1.49
GC-genes not detected in whole testis (5B) GO:0045449 Regulation of transcription 8.07
GO:0007156 Homophilic cell adhesion 3.04
GO:0045494 Photoreceptor cell maintenance 1.45
Cancer-specific genes that are not GC-genes (7B) GO:0006955 Immune response 2.24

Summary of gene ontology (GO) analysis of GC-genes. Enrichment equals −log10(p), where 1.3 is equivalent to p = 0.05 and p represents the geometric mean of p-values in an annotation cluster. Only a description of the first term of each statistically significant (enrichment > 1.3) annotation cluster is shown. Full results are shown in corresponding supplementary data for each subset (3B–G, 4B, 5B, and 7B)

aAs referred to in Fig. 1

bThese annotation clusters are not exactly the same, but both include the same GO-term, which has the lowest p-value in each cluster