Table 2.
GC-genes that are known to encode cell surface proteins
| Gene ID | Max. expressiona in germ cells [15] | Max. expressionb in non-cancerous somatic tissues (GTEx v4) | Max. expressionc in tumors (TCGAN 2016) | Number of tumor types that show RNA expression (TCGAN 2016) |
|---|---|---|---|---|
| CHRNA7 | 1.88 | 1.35 | 7.17 | 1 |
| CLEC12B | 4.14 | 1.21 | 7.13 | 1 |
| GP1BA | 1.91 | 1.39 | 8.02 | 2 |
| HMMR | 6.99 | 1.59 | 9.25 | 25 |
| IGLL1 | 6.50 | 0.39 | 8.09 | 2 |
| IL12RB2 | 3.27 | 1.13 | 8.46 | 5 |
| KCNH5 | 2.47 | 0.69 | 6.62 | 1 |
| LRFN4 | 5.61 | 0.94 | 10.04 | 32 |
| MPL | 3.47 | 0.40 | 8.23 | 1 |
| NLGN1 | 5.09 | 1.65 | 9.75 | 6 |
| NRG1 | 4.44 | 1.40 | 8.40 | 8 |
| PLK4 | 7.20 | 1.51 | 8.90 | 24 |
| SLC6A2 | 6.75 | 1.04 | 10.83 | 1 |
| TNFSF4 | 2.56 | 1.61 | 8.37 | 15 |
| TRPV1 | 4.06 | 0.83 | 8.57 | 31 |
| UMODL1 | 3.55 | 0.30 | 7.41 | 1 |
| WNT7A | 2.31 | 1.62 | 8.36 | 5 |
Seventeen GC-genes are known to encode cell surface proteins. Full results are shown in Supplementary Data 4A. A gene ontology analysis of these genes is available in Supplementary Data 4B
aMaximum expression of the gene across all stadia of germ cell development
bMaximum expression of the gene across all non-cancerous somatic (healthy) tissues (n = 49)
cMaximum expression of the gene across all tumor types (n = 33)