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. 2018 Oct 18;8:15349. doi: 10.1038/s41598-018-33778-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impulsivity and inattention of 6-OHDA mice in the 5-CSRTT. (A) Inter-trial interval (ITI) test in the 5-CSRTT. (A) significant increase in premature responding, perseverative responding and omissions was observed when the ITI was lengthened from 5 to 7 or 10 sec in 6-OHDA mice. (B) Stimulus duration (SD) test in the 5-CSRTT. (A) significant decrease in accuracy and an increase in omissions, premature response and perseverative responses were observed in 6-OHDA mice, when the SD was decreased from 1 to 0.8 or 0.5 s. (C) Effect of the drug treatment in the 5-CSRTT. Mph at 5.0 mg/kg produced a significant increase in accuracy, and a decrease in omissions, premature responding, and perseverative responses in 6-OHDA mice. Data represent percentage of accuracy, omissions, premature responding and perseverative responses. Data is expressed as mean ± SEM, n = 10 mice per group, **p < 0.01 and ***p < 0.001 vs sham; ^#p < 0.05 and ^##p < 0.01 vs vehicle.