Table 3.

Faecal microbiota composition of mice fed HDD or LDD and other host and environmental variables.

	Weighted UniFrac		Unweighted UniFrac
	R2	P value	R2	P value
Studies 1 and 3 combined (long- and short-term exposures)
Diet	0.198	0.001	0.287	0.001
Cumulative H2 production	0.098	0.023	0.173	0.001
Duration of intervention*	0.094	0.015	0.141	0.001
Age*	0.094	0.02	0.141	0.002
Sex	0.057	0.12	0.05	0.018
Body weight	0.08	0.042	0.1	0.002
Food intake	0.06	0.08	0.043	0.142
Starch intake	0.068	0.079	0.043	0.135
Study 1 (long-term exposure, post-weaning, n = 12)
Diet	0.26	0.003	0.4	0.001
Cumulative H2 production	0.198	0.005	0.344	0.001
Sex	0.062	0.195	0.03	0.658
Body weight	0.046	0.289	0.02	0.87
Food intake	0.099	0.062	0.049	0.3
Starch intake	0.1	0.077	0.05	0.279
Study 3 (short-term exposure, adult, n = 5)
Diet	0.24	0.056	0.293	0.004
Cumulative H2 production	0.14	0.217	0.108	0.5
Body weight	0.08	0.594	0.137	0.228
Food intake	0.06	0.748	0.192	0.044
Starch intake	0.06	0.761	0.192	0.05

Results are obtained using Adonis Permutational Multivariate Analysis of Variance. *Duration of intervention (short- and long-term) and age of animals (young vs adult) are not independent variables.