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. 2018 Oct 18;8:15440. doi: 10.1038/s41598-018-33901-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Autoimmune disease risk SNP rs2281808 causes low of SIRPγ expression on human T-cells. All the 79 PBMC samples from HD were subjected to flow cytometry staining and genotyping for rs2281808 using TaqMan chemistry. SIRPγ expression relative to rs2281808 genotyping status was analyzed on gated CD3 CD4 and CD3 CD8 T-cells (A–E). Representative histograms (A,C) and cumulative MFI data (B,D) are shown. CD8 T-cells showed a bimodal expression of SIRPγ, which was used to determine the frequency of SIRPγ^high and SIRPγ^low cells. The frequency of SIRPγ^low CD8 T-cells is shown in (E). Isotype staining is shown in grey. Gates are shown for SIRPγ^low cells. One-way ANOVA with Tukey’s posthoc test was performed and p < 0.05 was considered significant.