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. 2018 Oct 18;8:15440. doi: 10.1038/s41598-018-33901-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SIRPγ^low CD8 T-cells have a lower activation threshold. PBMC samples from CT carriers were stimulated with varying concentration of anti-CD3, followed by intra-cellular flow cytometric analysis to detect cytokine production by SIRPγ^low vs. SIRPγ^high gated subsets. SIRPγ^low CD8 T-cells responded to sub-optimal (lower concentrations) anti-CD3 stimulation by producing significantly greater levels of effector cytokines and granzyme (A). SIRPγ^high CD8 T-cells responded to only optimum (higher concentration) anti-CD3 stimulation (B). 2-way ANOVA with Tukey’s posthoc test was performed and p < 0.05 was considered significant.