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. 2018 Oct 18;8:15379. doi: 10.1038/s41598-018-33528-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Normal histology and histopathology of the testicle and epididymis of control and Zika vius infected Ifnar^−/− males. (A) Normal testicle from a sham-infected male. The interstitium contain Leydig (interstitial) cells and blood vessels. (B) Testis from a Zika virus infected Ifnar^−/− male with mild orchitis. Mild neutrophilic infiltration (arrow) is observed in the interstitium. (C) Normal epididymis from a sham-infected male. (D) Epididymis from a Zika virus infected male exhibiting mild epididymitis. There is neutrophilic infiltration (arrow) of interstitium and individual epithelial cell necrosis (arrowhead). All sections 400x magnification; hematoxylin and eosin stain; bar = 50 µm.