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. 2018 Oct 18;8:15383. doi: 10.1038/s41598-018-33784-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The combination treatment of ABT263 and selinexor shows features of apoptotic cell death. (A) LN229, T98G and U87 GBM cells were treated with ABT263, selinexor or the combination. After 72 h, cells were harvested, fixed, stained with propidium iodide and analyzed by flow cytometric analysis for DNA – fragmentation. Shown are representative flow cytometry plots. (B) The same set of cell lines as in A were treated with the indicated drugs and the same conditions (except for the incubation time, which was 24 h). Thereafter, cells were stained with Annexin V/Propidium iodide and analyzed by multi-parametric flow cytometry. Shown are representative plots. (C) The same set of cell lines as in A were treated with the indicated drugs and the same conditions (except for the incubation time, which was 24 h). Thereafter, cells were stained with TMRE and analyzed by flow cytometry. Shown are representative flow plots.