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. 2018 Oct 18;8:15384. doi: 10.1038/s41598-018-33736-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Upper row: Enchondroma of a 12-year old girl treated by curettage and defect-filling using CERAMENT|BONE VOID FILLER. (A,B) Pre-operative MRI and x-ray showing decreased cortical thickness. (C) X-ray taken post-operatively showing near complete defect-filling. (D,E) X-rays taken after 6 weeks, and 6 months showing increasing product resorption and cortical thickening. (F) X-ray taken after 12 months showing normal cortical thickness and signs of cavity-remodeling. Lower row: Large bone infarction of the proximal tibia treated by curettage and defect-filling using CERAMENT|BONE VOID FILLER. (G,H) Pre- and post-operative x-rays showing decreased cavity radiolucency and near complete defect-filling. (I–K) X-rays taken after 6 weeks, and 3 and 6 months showing increasing product resorption and persistent reduced defect-radiolucency. (L) 6-months CT-scan showing a peripheral reactive zone in the defect and a seemingly empty cavity.