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. 2018 Oct 18;9:4335. doi: 10.1038/s41467-018-06574-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Treatment of orthotopic liver cancer. Tumor volume changes of the mice bearing orthotopic LM3 tumors treated with a PBS, b cPt, c MNPs, d TPPNPs + L, or e MNPs + L after one injection (n = 6). f Kaplan–Meier survival curves of the mice bearing orthotopic LM3 tumors treated with different formulations. g Photo images of the liver tissues containing LM3 tumors collected from the mice treated with different formulations. h H&E and Ki67 staining of the liver tissues from each group. The white dashed circles denote the tumor tissues. Scale bar is 500 μM. i PET/CT images of the mice treated with different formulations. The red dash circles denote the orthotopic hepatocellular carcinoma tumors. (j) MRI images of the mice treated with different formulations. The red dashed circles denote the orthotopic hepatocellular carcinoma tumors. The laser density was 0.3 W cm^–2 at 671 nm, and the irradiation time was 10 min. The data are expressed as means ± s.d