Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 18;8:15385. doi: 10.1038/s41598-018-33979-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

HSC numbers are decreased in the BM of CRF mice. (A) Scheme of hematopoiesis and the phenotypes of HSC, HPC and MPP. LSK indicates Lin⁻Sca-1^POSc-Kit^HI cells. Common myeloid progenitor (CMP), common lymphoid progenitor (CLP) (B) FACS plots for the identification of stem cell subsets. Representative plots for sham-operated controls (sham) and CRF mice are shown. Using FACS analysis the frequency of (C) MPP, (D) short-term repopulating HPC and (E) long-term repopulating HSC were determined phenotypically (n = 9–13/group). The percentages in the dotplot (B) refer to the percentages of MPP, HPC and HSC in the LSK population, while the percentages in the graphs (C–E) refer to the percentages of cells with all bone marrow cells. Using a CAFC assay, the frequency of CAFC (F) week 3, (G) week 4 and (H) week 5 was assessed functionally (n = 8 per group). Means ± SD are depicted. ^*p < 0.05 and ^**<0.01.