Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 18;8:15385. doi: 10.1038/s41598-018-33979-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

HSC compartment is impaired in CKD-MBD mice. (A) BMC obtained from CKD-MBD mice and sham-operated controls were harvested and transplanted into healthy, lethally irradiated, congenic recipients. At 24 weeks after transplantation, BMC obtained from primary recipients were harvested, pooled, analyzed for LSK chimerism (E), and re-transplanted into lethally irradiated secondary recipients. At three-week intervals, donor chimerism was analyzed in (B–D) primary and (E–G) secondary recipients. (B,E) Donor-derived CD45⁺ cells and (C,F) granulocytes were assessed. (D,G) At 18–24 weeks after transplantation the percentage of donor-derived CD45⁺ cells, granulocytes, Lin^negSca-1^posc-kit^hi (LSK) cells and CD34^negLSK (HSC) in the spleen and BM were analyzed. ^*p < 0.05 and ^**p < 0.01. In panel B–G, each dot represents a single mouse.