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. 2018 Oct 18;8:15369. doi: 10.1038/s41598-018-33746-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rescue of the heart looping by smarce1 mRNA injection in smarce1 mutant embryos. Whole-mount in situ hybridization detects transcripts for the cardiomyocyte marker cmlc2. A-B. Embryos at 48 hpf showing a normal heart (A) and a smarce1^−/− heart with a defective looping (B). (C–H) Analysis of heart looping at 72 hpf. Buffer injected embryos present a normal heart in control siblings (C) and a non-looped heart in all the mutants (D). (E–H) smarce1 mRNA injected embryos showing the rescue of the heart looping in the mutant embryos. Complete rescue is shown in (F); a partial rescue in (G); and the failing of rescue in (H). Scale bars: 50 μm.