58. Best practice*.mp.      59. benefit*.mp.      60. concern*.mp.      61. confidential*.mp.      62. cost*.mp. or cost-effect* or effective*      63. impact*.mp. or limitation**.mp. or negativ*.mp. or positive*.mp. or problem*.mp.      64. risk*.mp. or harm*.mp. or safety.mp.      65. troll*.mp. or trend*.mp.      66. or/ 58-65

SR Filter (to filter out non-systematic review research)

67. meta analysis.mp,pt.      68. systematic review.mp,pt.      69. search*.tw.      70. or/67-69 [HIRU SR filter to balance sensitivity and specificity]

Limits: publication years 2003-2016