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. 2018 Oct 18;1:172. doi: 10.1038/s42003-018-0174-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — EDEM1 and EDEM2 associate with the oxidoreductases PDI and TXNDC11. a HEK 293 cells expressing EDEM1-HA, together with FLAG-TXNDC11 or FLAG-PDI as indicated were lysed in mild conditions. Lysates were immunoprecipitated with anti-EDEM1 or control antibody (lane 3), subjected to SDS-PAGE and immunoblotted with anti-FLAG or anti-EDEM1. The asterisk indicates a non-specific band of antibody heavy chain. Quantitation showed 15-fold stronger coIP of EDEM1 with TXNDC11. The results shown are representative of three repeat experiments. b Similar to a but with EDEM2 instead of EDEM1. Quantitation showed a moderately stronger association of EDEM2 with TXNDC11 than with PDI