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. 2018 Oct 18;8:15423. doi: 10.1038/s41598-018-33641-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Eosin red (left) and Chicago blue (right) dyes were loaded into the inlets to characterize the gradient of two solutions generated in the microfluidic channels. The dyes were left in the chip for 24 hours to diffuse into the hydrogel, but was unable to cross the gradient generating gap between channels. Gradient generating gaps are marked with white arrows (a). The layout of the brain cancer chip flows solution loaded into the two inlets, through a gradient generating regions, and into 7 microfluidic channels, each containing a culture array composed of 9–11 microwells 360 µm in diameter (b). The image was taken at day 7 to test the leakage (c). The coins are a US Quarter.