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. 2018 Oct 18;8:15389. doi: 10.1038/s41598-018-33830-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Clustered data from a monocentric whole brain-based spatial statistics of FA maps of 370 ALS patients vs 140 controls. Microstructural alterations were observed along the CST, along the corticorubral and the corticopontine tracts, the corticostriatal pathway, and in hippocampal regions. (B) Overlay of WBSS and meta-analysis results.