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. 2018 Oct 18;8:15389. doi: 10.1038/s41598-018-33830-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results at different statistical power thresholds revealed a pattern of sequential involvement of ALS-specific white matter regions. Specific involvement of the CST at the highest threshold (ALS stage 1), followed by additional involvement of corticorubral/-pontine tract together with corticostriatal pathways at a lower frequency of alteration threshold (ALS stages 2 and 3), and. finally, revealing also hippocampal involvement for the lowest threshold corresponding to the proximal portion of the perforant path (ALS stage 4). Hot colors encode the frequency of alteration. (A) Results of the meta-analysis. (B) Results clusters of the WBSS of FA maps. (C) Simulation pattern of ALS-associated spread of TDP-43 pathology.