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. 2018 Oct 18;8:15363. doi: 10.1038/s41598-018-33696-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristics of the three miRNAs associated with poor prognoses. (a) Density scatter plots showing the association between miRNA (miR-296-5p, miR-324-3p, and miR-3928-3p) expression and CNV in the precursor locus, particularly for copy number gains. The curved line was estimated with R function “lowess”. (b) Boxplots showing the higher expression of the three miRNAs of interest in Sq samples relative to those in Ad and normal (N) samples. P-values were calculated with the Wilcoxon rank sum test: (*) P-value < 0.05; (**) P-value < 0.01.