Table 2.
Univariate and multivariate analyses using Cox proportional hazards models.
| Model | Variables | Hazard_ratio (lower 95% CI–upper 95% CI) | P-value |
|---|---|---|---|
| Uivariate | |||
| miR-296 | miR-296 | 1.75 (1.05–2.90) | 3.21E-02 |
| miR-324 | miR-324 | 1.76 (1.06–2.92) | 2.82E-02 |
| miR-3928 | miR-3928 | 1.67 (1.00–2.79) | 4.92E-02 |
| 3 miRNAs high | 3 miRNAs high | 2.59 (1.54–4.35) | 3.30E-04 |
| Stage | Stage | 0.68 (0.37–1.23) | 1.96E-01 |
| Smoking | Smoking | 1.56 (0.91–2.67) | 1.01E-01 |
| Age | Age | 0.93 (0.55–1.57) | 7.78E-01 |
| Sex | Sex | 1.09 (0.59–2.03) | 7.77E-01 |
| Multivariate | |||
| Model | Variables | Hazard_ratio | P-value |
| miR-296 + clinical covariates | miR-296 | 1.97 (1.16–3.33) | 1.22E-02 |
| Stage | 0.59 (0.32–1.09) | 9.23E-02 | |
| Smoking | 1.67 (0.97–2.86) | 6.31E-02 | |
| Age | 0.90 (0.53–1.53) | 7.00E-01 | |
| Sex | 1.11 (0.59–2.09) | 7.40E-01 | |
| miR-324 + clinical covariates | miR-324 | 1.89 (0.31–0.89) | 1.58E-02 |
| Stage | 0.67 (0.36–1.22) | 1.88E-01 | |
| Smoking | 1.58 (0.92–2.74) | 9.97E-02 | |
| Age | 0.885 (0.52–1.52) | 6.75E-01 | |
| Sex | 1.10 (0.59–2.07) | 7.66E-01 | |
| miR-3928 + clinical covariates | miR-3928 | 1.95 (1.14–3.31) | 1.41E-02 |
| Stage | 0.60 (0.32–1.10) | 9.57E-02 | |
| Smoking | 1.60 (0.93–2.76) | 9.27E-02 | |
| Age | 0.86 (0.50–1.48) | 5.86E-01 | |
| Sex | 1.06 (0.56–2.00) | 8.53E-01 | |
| 3 miRNAs high + clinical covariates | 3 miRNAs high | 2.84 (1.65–4.87) | 1.60E-04 |
| Stage | 0.65 (0.36–1.19) | 1.65E-01 | |
| Smoking | 1.73 (1.00–2.99) | 4.995E-02 | |
| Age | 1.07 (0.61–1.87) | 8.05E-01 | |
| Sex | 1.12 (0.59–2.10) | 7.33E-01 | |
| clinical covariates: Stage + Smoking + Age + Sex | |||
| Italic number: P-value < 0.05 | |||
| CI: confidential interval | |||
Univariate and Multivariate analysis Univariate.