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. 2018 Oct 18;8:15402. doi: 10.1038/s41598-018-33865-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HPV16-immortalized cells from TZ and endocervix have more Ki-67 positive cells. (a) HPV16-immortalized cell lines derived from ectocervix, TZ, or endocervix were maintained for 10 days on collagen rafts with cervical stromal cells and then stained with DAPI to visualize cell nuclei and Ki-67 antibody to show proliferating cells. Cervical cancer cells served as a positive control for cell proliferation. Dotted lines indicate position of basement membrane and upper extent of epithelial cells. (b) Mean percentage of Ki-67 positive cells ± standard error of 12 different HPV16-immortalized cell lines (4 from ectocervix, TZ and endocervix) maintained in organotypic culture on rafts formed with cervical stromal cells. Bars above graph show values that are statistically different (3 asterisks = p < 0.001).