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. 2018 Oct 18;8:15402. doi: 10.1038/s41598-018-33865-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HPV16-immortalized cells from TZ and endocervix are more invasive. (a) HPV16-immortalized cells derived from ectocervix, TZ, or endocervix (all 85 population doublings) were grown for 10 days on rafts with either 3T3-J2 mouse cells or human stromal cells. Dotted lines indicate position of basement membranes. (b) Mean invasion index (degree of invasion into collagen raft) ± standard error of 24 different HPV16-immortalized cell lines (8 from ectocervix, TZ and endocervix) maintained in organotypic culture on rafts formed with 3T3-J2 cells or human stromal cells. Bars show values that are statistically different (3 asterisks = p < 0.001).